(figuratively) An internal tormentor; something that gnaws or afflicts one’s mind with remorse.
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The worm of conscience still begnaw thy soul!
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c. 1593 (date written), William Shakespeare, “The Tragedy of Richard the Third: […]”, in Mr. William Shakespeares Comedies, Histories, & Tragedies […] (First Folio), London: […] Isaac Iaggard, and Ed[ward] Blount, published 1623, →OCLC, [Act I, scene iii]: